Endocrine Abstracts

Background: Non-functioning pituitary tumours can be associated with a modestly elevated prolactin. Response to dopamine agonist therapy in such cases is unusual. Large macroprolactinomas are associated with much higher prolactin levels and respond well to dopamine agonists.Case: We report a 41-year-old man with a pituitary macroadenoma associated with an elevated prolactin of around 2000mIU/l who developed marked resolution in his pituitary MRI images r...

Background: Inclisiran is the first clinically available small interfering RNA (siRNA)-based treatment, has been shown to reduce pro-atherogenic lipoproteins in patients with or without familial hypercholesterolemia (FH), diabetes mellitus (DM), or atherosclerotic cardiovascular disease (ASCVD), but has not been evaluated in Middle Eastern populations.Methods: Retrospective review of patients initiating inclisiran treatment for any indication at our cent...

IntroductionFollowing the WHO declaration of COVID-19 as a pandemic and as many countries around the world, the United Arab Emirates government introduced gradual measures to stop the spread of the virus placing the country in a state of almost complete-lockdown. We report the impact of these restrictions on glucose control in patients with type 1 diabetes (T1D) and type 2 diabetes (T2D) on insulin therapy.Methods<p class="abst...

Purpose: Inclisiran is the first small interfering RNA (siRNA)-based treatment approved to reduce pro-atherogenic lipoproteins in patients with heterozygous familial hypercholesterolemia (HeFH) or clinical atherosclerotic cardiovascular disease (ASCVD), who require additional lowering of low-density lipoprotein cholesterol (LDL-C). We report, to the best of our knowledge, the first evaluation of its effects in a Middle Eastern population.Methods: Retrosp...

Camel milk provides a modest portion of the overall global milk share but is an important source of protein in arid regions. Perceived health benefits include anti-diabetic properties attributed to its unique composition. We hypothesise that exogenous insulin present in camel milk mediates a hypoglycaemic effect. In a randomised, double blind crossover study, eleven normoglycaemic individuals were allocated to receive a 300 kcal pre-load of camel milk or cow milk ten minutes p...

We report the case of a 28-year-old Emirati lady with type 1 diabetes (weight 51 kg, BMI 20.82 kg/m2) diagnosed at 3 years of age who presented to our centre with problems at her insulin injection sites. She had poor glycaemic control and her diabetes was complicated by retinopathy; other past medical history included vitamin D deficiency. All her seven siblings had diabetes and were on insulin; both parents had type 2 diabetes.In 2017, she wa...

Introduction: We have previously shown good short-term but variable long-term weight loss outcomes of bariatric surgery (BS) in a cohort of obese patients with MC4R deficiency. This study aims to elucidate the epidemiological landscape of Monogenic Obesity (MO) and quantify bariatric surgery’s effectiveness in weight reduction among Emirati patients with severe obesity. Methods: We selected a group of patients with extreme obesity (>50 kg/m...